![]() central diabetes insipidus (lack of ADH)ģ. primary polydipsia (psychogenic water drinking)Ģ. idiopathic diabetes insipidus - 3 major causes of polyuria 1. suspect when there is hyponatremia & urine osmolality >100 SIADH causes 1. primarily the visceral blood vessels inappropriate ADH secretion (SIADH) -ADH secretion in the setting of water overload or a hyperosmolar state sepsis high levels of ADH cause vasoconstriction osmotic (mannitol) extreme amounts of ADH are secreted w/ -severe hypotension &/or hypovolemia "cotton mouth" w/ hangover what does excess water consumption cause with ADH inhibition ADH actions are opposed by diuretics nicotine ADH secretion is inhibited by -alcohol increased free water reabsorption by the kidneys what do osmoreceptors stimulate the neurosecretory neurons to release ADH ADH secretion is also stimulated by -hypotension increase free water excretion by the kidneys high osmotic pressure -dehydration What monitors plasma osmotic pressure in the hypothalamus chemoreceptors (osmoreceptors) low osmotic pressure -water overload
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